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1

The Contribution of Small Airway Obstruction to the Pathogenesis of Chronic Obstructive Pulmonary Disease

Hogg, James C., Paré, Peter D., Hackett, Tillie-Louise

Journal:

Physiological Reviews

Year:

2017

Language:

english

File:

PDF, 3.01 MB

english, 2017

2

Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression

Negar Asdaghi, Ruhangiz T. Kilani, Azadeh Hosseini-Tabatabaei, Solomon O. Odemuyiwa, Tillie-Louise Hackett, Darryl A. Knight, Aziz Ghahary, Redwan Moqbel

Journal:

Molecular and Cellular Biochemistry

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

3

Characterization of Side Population Cells from Human Airway Epithelium

Tillie-Louise Hackett, Furquan Shaheen, Andrew Johnson, Samuel Wadsworth, Dmitri V. Pechkovsky, David B. Jacoby, Anthony Kicic, Stephen M. Stick, Darryl A. Knight

Journal:

Year:

2008

Language:

english

File:

PDF, 2.16 MB

english, 2008

4

Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease

Tillie L Hackett, Marco Scarci, Lu Zheng, Wan Tan, Tom Treasure, Jane A Warner

Journal:

Respiratory Research

Year:

2010

Language:

english

File:

PDF, 458 KB

english, 2010

5

Functional genomics of human bronchial epithelial cells directly interacting with conidia ofAspergillus fumigatus

Pol Gomez, Tillie L Hackett, Margo M Moore, Darryl A Knight, Scott J Tebbutt

Journal:

Year:

2010

Language:

english

File:

PDF, 959 KB

english, 2010

6

E-cadherin: gatekeeper of airway mucosa and allergic sensitization

Martijn C. Nawijn, Tillie L. Hackett, Dirkje S. Postma, Antoon J.M. van Oosterhout, Irene H. Heijink

Journal:

Trends in Immunology

Year:

2011

Language:

english

File:

PDF, 732 KB

english, 2011

7

Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis

Grethe Neumann Andersen, Kenneth Nilsson, Jamshid Pourazar, Tillie-Louise Hackett, Elsadig Kazzam, Anders Blomberg, Anders Waldenström, Jane Warner, Solbritt Rantapää-Dahlqvist, Lucia Mincheva-Nilsson

Journal:

Respiratory Medicine

Year:

2007

Language:

english

File:

PDF, 202 KB

english, 2007

8

IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7–mediated Fas ligand cleavage from bronchial epithelial cells

Wadsworth, Samuel J., Atsuta, Ryo, McIntyre, J. Oliver, Hackett, Tillie-Louise, Singhera, Gurpreet K., Dorscheid, Delbert R.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 1.64 MB

english, 2010

9

Defective function at the epithelial junction: A novel therapeutic frontier in asthma?

Knight, Darryl A., Stick, Stephen M., Hackett, Tillie-Louise

Journal:

Journal of Allergy and Clinical Immunology

Year:

2011

Language:

english

File:

PDF, 57 KB

english, 2011

10

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

Hirota, Jeremy A., Hirota, Simon A., Warner, Stephanie M., Stefanowicz, Dorota, Shaheen, Furquan, Beck, Paul L., MacDonald, Justin A., Hackett, Tillie-Louise, Sin, Don D., Van Eeden, Stephan, Knight,

Journal:

Journal of Allergy and Clinical Immunology

Year:

2012

Language:

english

File:

PDF, 1.77 MB

english, 2012

11

Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: anex vivostudy

Tillie-Louise Hackett, Rebecca Holloway, Stephen T Holgate, Jane A Warner

Journal:

Respiratory Research

Year:

2008

Language:

english

File:

PDF, 1.30 MB

english, 2008

12

Caveolin-1 Controls Airway Epithelial Barrier Function. Implications for Asthma

Hackett, Tillie-Louise, de Bruin, Harold G., Shaheen, Furquan, van den Berge, Maarten, van Oosterhout, Antoon J., Postma, Dirkje S., Heijink, Irene H.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 2.02 MB

english, 2013

13

A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK

Joshua D Campbell, John E McDonough, Julie E Zeskind, Tillie L Hackett…

Journal:

Genome Medicine

Year:

2012

Language:

english

File:

PDF, 788 KB

english, 2012

14

Transcription Factor p63 Regulates Key Genes and Wound Repair in Human Airway Epithelial Basal Cells

Warner, Stephanie M. B., Hackett, Tillie-Louise, Shaheen, Furquan, Hallstrand, Teal S., Kicic, Anthony, Stick, Stephen M., Knight, Darryl A.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 982 KB

english, 2013

15

Mesenchymal stem cells for repair of the airway epithelium in asthma

Knight, Darryl A, Rossi, Fabio M, Hackett, Tillie-Louise

Journal:

Expert Review of Respiratory Medicine

Year:

2010

Language:

english

File:

PDF, 822 KB

english, 2010

16

Airway epithelial regulation of pulmonary immune homeostasis and inflammation

Hallstrand, Teal S., Hackett, Tillie L., Altemeier, William A., Matute-Bello, Gustavo, Hansbro, Philip M., Knight, Darryl A.

Journal:

Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

17

Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease

Aminuddin, Farzian, Hackett, Tillie-Louise, Stefanowicz, Dorota, Saferali, Aabida, Paré, Peter D, Gulsvik, Amund, Bakke, Per, Cho, Michael H, Litonjua, Augusto, Lomas, David A, Anderson, Wayne H, Beat

Journal:

BMC Pulmonary Medicine

Year:

2013

Language:

english

File:

PDF, 726 KB

english, 2013

18

Pathological changes in the COPD lung mesenchyme – Novel lessons learned from in vitro and in vivo studies

Ojo, Oluwaseun, Lagan, Anna L., Rajendran, Vijayanand, Spanjer, Anita, Chen, Ling, Sohal, Sukhwinder Singh, Heijink, Irene, Jones, Robin, Maarsingh, Harm, Hackett, Tillie L.

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 813 KB

english, 2014

19

Formation of a Stable Mimic of Ambient Particulate Matter Containing Viable Infectious Respiratory Syncytial Virus and Its Dry-Deposition Directly onto Cell Cultures

Cruz-Sanchez, Teresita M., Haddrell, Allen E., Hackett, Tillie L., Singhera, Gurpreet K., Marchant, David, Lekivetz, Ryan, Meredith, Anna, Horne, Derrick, Knight, Darryl A., van Eeden, Stephen F., Bai

Journal:

Analytical Chemistry

Year:

2013

Language:

english

File:

PDF, 4.76 MB

english, 2013

20

Ultrastructure of Human Tracheal Smooth Muscle from Subjects with Asthma and Nonasthmatic Subjects. Standardized Methods for Comparison

Syyong, Harley T., Pascoe, Chris D., Zhang, Jenny, Arsenault, Bryna A., Solomon, Dennis, Elliott, W. Mark, Hackett, Tillie L., Walker, David C., Paré, Peter D., Seow, Chun Y.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.61 MB

english, 2015

21

Fibroblast Signal Transducer and Activator of Transcription 4 Drives Cigarette Smoke–Induced Airway Fibrosis

Hackett, Tillie-Louise, Shaheen, Furquan, Zhou, Steven, Wright, Joanne L., Churg, Andrew

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 2.04 MB

english, 2014

22

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] A36. CYTOKINES AND CHEMOKINES IN AIRWAYS DISEASE - Environmental Challenges And IL-33 Release By Airway Epithelial Cells

Singhera, Gurpreet K., Hirota, Jeremy A., Hackett, Tillie-Louise, Hallstrand, Teal S., Knight, Darryl A., Dorscheid, Delbert R.

Year:

2012

Language:

english

File:

PDF, 17 KB

english, 2012

23

Induction of Epithelial–Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-β1

Hackett, Tillie-Louise, Warner, Stephanie Mary, Stefanowicz, Dorota, Shaheen, Furquan, Pechkovsky, Dmitri V., Murray, Lynne A., Argentieri, Rochelle, Kicic, Anthony, Stick, Stephen M., Bai, Tony R., K

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2009

Language:

english

File:

PDF, 2.31 MB

english, 2009

24

Intrinsic Phenotypic Differences of Asthmatic Epithelium and Its Inflammatory Responses to Respiratory Syncytial Virus and Air Pollution

Hackett, Tillie-Louise, Singhera, Gurpreet K., Shaheen, Furquan, Hayden, Patrick, Jackson, George R., Hegele, Richard G., Van Eeden, Stephan, Bai, Tony R., Dorscheid, Delbert R., Knight, Darryl A.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

25

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

Hao, Ke, Bossé, Yohan, Nickle, David C., Paré, Peter D., Postma, Dirkje S., Laviolette, Michel, Sandford, Andrew, Hackett, Tillie L., Daley, Denise, Hogg, James C., Elliott, W. Mark, Couture, Christia

Journal:

Year:

2012

Language:

english

File:

PDF, 659 KB

english, 2012

26

Modeling Asthma in Mice

Hirota, Jeremy A., Hackett, Tillie-Louise, Inman, Mark D., Knight, Darryl A.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 101 KB

english, 2011

27

Human Lung Parenchyma but Not Proximal Bronchi Produces Fibroblasts with Enhanced TGF-β Signaling and α-SMA Expression

Pechkovsky, Dmitri V., Hackett, Tillie L., An, Steven S., Shaheen, Furquan, Murray, Lynne A., Knight, Darryl A.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.55 MB

english, 2010

28

Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription

Faura Tellez, Grissel, Vandepoele, Karl, Brouwer, Uilke, Koning, Henk, Elderman, Robin M., Hackett, Tillie-Louise, Willemse, Brigitte W. M., Holloway, John, Van Roy, Frans, Koppelman, Gerard H., Nawij

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

29

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

Jamil, Sarwat, Stoica, Cezar, Hackett, Tillie-Louise, Duronio, Vincent

Journal:

Year:

2010

Language:

english

File:

PDF, 2.54 MB

english, 2010

30

ID: 247

Dockstader, Kristy L., Fonseca, Nicolette M., Hackett, Tillie L., Perona-Wright, Georgia

Journal:

Year:

2015

Language:

english

File:

PDF, 58 KB

english, 2015

31

Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects

Stefanowicz, Dorota, Lee, Ja Young, Lee, Kevin, Shaheen, Furquan, Koo, Hyun-Kyoung, Booth, Steven, Knight, Darryl A., Hackett, Tillie-Louise

Journal:

Respiratory Research

Year:

2015

Language:

english

File:

PDF, 2.69 MB

english, 2015

32

Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects

Hosseini, Ali, Hirota, Jeremy A., Hackett, Tillie L., McNagny, Kelly M., Wilson, Susan J., Carlsten, Chris

Journal:

Particle and Fibre Toxicology

Year:

2015

Language:

english

File:

PDF, 2.78 MB

english, 2015

33

Epithelial–mesenchymal transition in the pathophysiology of airway remodelling in asthma

Hackett, Tillie-Louise

Journal:

Current Opinion in Allergy and Clinical Immunology

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

34

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D77. AIRWAY CELL DIFFERENTIATION AND INJURY: TWO SIDES OF A COIN - Resetting Airway Epithelial Differentiation In Asthma By Modifying ²-Catenin Signaling

Roth, Hollis M., Shaheen, Furquan, Hackett, Tillie-Louise, Utokaparch, Soraya, Minna, John D., Kahn, Michael, Knight, Darryl A.

Year:

2012

Language:

english

File:

PDF, 18 KB

english, 2012

35

The role of epithelial injury and repair in the origins of asthma

Hackett, Tillie-Louise, Knight, Darryl A

Journal:

Current Opinion in Allergy and Clinical Immunology

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

36

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

Osei, Emmanuel T., Noordhoek, Jacobien A., Hackett, Tillie L., Spanjer, Anita I.R., Postma, Dirkje S., Timens, Wim, Brandsma, Corry-Anke, Heijink, Irene H.

Journal:

European Respiratory Journal

Year:

2016

Language:

english

File:

PDF, 486 KB

english, 2016

37

Selective targeting of CBP/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle

Koopmans, Tim, Crutzen, Stijn, Menzen, Mark H, Halayko, Andrew J, Hackett, Tillie-Louise, Knight, Darryl A, Gosens, Reinoud

Journal:

British Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 965 KB

english, 2016

38

A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma

Hackett, Tillie-Louise, Ferrante, Sarah C, Hoptay, Claire E, Engelhardt, John F, Ingram, Jennifer L, Zhang, Yulong, Alcala, Sarah E, Shaheen, Furquan, Matz, Ethan, Pillai, Dinesh K, Freishtat, Robert

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 2.85 MB

english, 2016

39

Statins reduce the burden of ambient particulate matter and inflammatory cells within the lung tissues of smokers with and without COPD

Hiraiwa, Kunihiko, Miller, Sally, Ngan, David A., Vasilescu, Dragoş M., Hackett, Tillie-Louise, Kinose, Daisuke, Cheng, Jui Chih, van Eeden, Stephan F.

Journal:

European Respiratory Journal

Year:

2017

Language:

english

File:

PDF, 288 KB

english, 2017

40

Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts

Stefanowicz, Dorota, Ullah, Jari, Lee, Kevin, Shaheen, Furquan, Olumese, Ekiomoado, Fishbane, Nick, Koo, Hyun-Kyoung, Hallstrand, Teal S., Knight, Darryl A., Hackett, Tillie-Louise

Journal:

BMC Pulmonary Medicine

Year:

2017

Language:

english

File:

PDF, 1.83 MB

english, 2017

41

Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and nonasthmatics

Pascoe, Christopher D., Seow, Chun Y., Hackett, Tillie L., Paré, Peter D., Donovan, Graham M.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2017

Language:

english

File:

PDF, 220 KB

english, 2017

42

miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD

Osei, Emmanuel T., Florez-Sampedro, Laura, Tasena, Hataitip, Faiz, Alen, Noordhoek, Jacobien A., Timens, Wim, Postma, Dirkje S., Hackett, Tillie L., Heijink, Irene H., Brandsma, Corry-Anke

Journal:

European Respiratory Journal

Year:

2017

Language:

english

File:

PDF, 632 KB

english, 2017

43

Application of Euclidean Distance Mapping for Assessment of Basement Membrane Thickness Distribution in Asthma

Mostaco-Guidolin, Leila B., Hajimohammadi, Soheil M., Vasilescu, Dragos Mihai, Hackett, Tillie-Louise

Journal:

Journal of Applied Physiology

Year:

2017

Language:

english

File:

PDF, 3.56 MB

english, 2017

44

Co-exposure to allergen and diesel exhaust enhance inflammatory responses in human airway submucosa

Ali Hosseini,Tillie L Hackett,Jeremy Hirota…

Journal:

Allergy, Asthma & Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 217 KB

english, 2014

45

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)

Eapen, Mathew Suji, Hansbro, Philip M., McAlinden, Kielan, Kim, Richard Y., Ward, Chris, Hackett, Tillie-Louise, Walters, Eugene H., Sohal, Sukhwinder Singh

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.94 MB

english, 2017

46

Gene expression signature of the ageing lung: breathing new life into COPD

Booth, Steven, Hackett, Tillie-Louise

Journal:

Year:

2018

Language:

english

File:

PDF, 200 KB

english, 2018

47

Structure and Function Relationships in Diseases of the Small Airways

Hogg, James C., Hackett, Tillie-Louise

Journal:

Annals of the American Thoracic Society

Year:

2018

Language:

english

File:

PDF, 1.02 MB

english, 2018

48

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Clifford, Rachel L., Fishbane, Nick, Patel, Jamie, MacIsaac, Julia L., McEwen, Lisa M., Fisher, Andrew J., Brandsma, Corry-Anke, Nair, Parameswaran, Kobor, Michael S., Hackett, Tillie-Louise, Knox, Al

Journal:

Clinical Epigenetics

Year:

2018

Language:

english

File:

PDF, 1.28 MB

english, 2018

49

Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

Boivin, Wendy A., Shackleford, Marlo, Vanden Hoek, Amanda, Zhao, Hongyan, Hackett, Tillie L., Knight, Darryl A., Granville, David J., Reitsma, Pieter H.

Journal:

Year:

2012

Language:

english

File:

PDF, 558 KB

english, 2012

50

Expression of Myoferlin in Human Airway Epithelium and Its Role in Cell Adhesion and Zonula Occludens-1 Expression

Leung, Cleo, Shaheen, Furquan, Bernatchez, Pascal, Hackett, Tillie-Louise, Fuxe, Jonas

Journal:

Year:

2012

Language:

english

File:

PDF, 2.06 MB

english, 2012